Compounded ketamine is used at low and carefully controlled doses to help manage treatment-resistant depression, anxiety, and certain chronic pain conditions.
Unlike standard antidepressants or pain medications, ketamine works through a different pathway in the brain. It is not a first‑line treatment, but many patients who have not found relief with other options have turned to low‑dose ketamine therapy.
Your compounded ketamine has been prepared specifically for you by our pharmacy, in the form and strength prescribed by your healthcare provider.
Ketamine influences a brain chemical called glutamate, which plays a key role in mood regulation, learning, and pain signaling. By temporarily blocking NMDA receptors, it stops the inhibition signal and allows a glutamate “surge” in the brain.
Glutamate supports neuroplasticity and the formation of new neuronal pathways. Strengthening synaptic connections is associated with rapid antidepressant effects.
One of the most notable features of ketamine is its speed. Some patients feel improvement within 60 minutes of taking their prescribed dose.
However, the full benefits often build over several days or weeks with repeated use as directed by your doctor.
With ongoing treatment, the positive effects may last longer. Some patients experience relief that continues for days to weeks after a dose.
Your doctor will recommend a schedule that works best for your condition.
Common side effects may include:
Important: Do not drive, operate machinery, or make important decisions for several hours after taking ketamine. Even if you feel fine, ketamine may slow your reaction time.
Ketamine patients are not at risk for neurological (physical) addiction, meaning you won’t get painful withdrawal effects if you abruptly stop your medication.
The low doses used in compounded therapy show a very low risk of psychological addiction, however. There is a potential for misuse due to the euphoric sensation many patients experience. Always follow your prescriber’s instructions carefully and never increase your dose on your own.
Ketamine is available in several compounded forms. Follow the specific directions on your prescription label.
Below are general guidelines for common forms:
General reminder for all forms:
If you miss a dose, contact your pharmacist or doctor for guidance. Do not double up.
Reach out to your healthcare team if you experience:
For medical emergencies, call 911 or go to the nearest emergency room.
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Whether you need a refill, have a question about side effects, or just want to double‑check how to take your LDN, we’re here to help.
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All ClearSpring Pharmacy locations will be closed in observance of Memorial Day, Saturday, July 4th, 2026.
Normal business hours will resume on Monday.
A nationwide shortage of estradiol patches is affecting major pharmacies and may continue for up to 3 years.
Affected brands include:
You don’t need to wait until you run out. Compounding pharmacies are experts at stepping in when drug shortages occur.
We have topical options such as creams or troches, and we work with your doctor to ensure your care stays on track.