Fibromyalgia is a debilitating and complex ailment that can be difficult to pinpoint. The consistent pain and exhaustion from fibromyalgia can lead to an extreme reduction in quality of life, especially when traditional medications don’t work.
Low dose naltrexone (LDN) has shown promise in many cases to improve fibromyalgia symptoms. Patients have reported positive outcomes when using LDN to help with their chronic pain.
LDN has emerged as a suitable option for many patients who have fibromyalgia.
Responses vary. Some see changes in weeks but in general most will experience the full effects after 2 months of use.
Consistency is key and it is important to track symptoms and work with your prescriber.
Most are mild: vivid dreams, sleep disturbances, or temporary headaches.
These often fade within weeks. We adjust doses to minimize reactions.
Research explores LDN for fibromyalgia, Crohn’s disease, MS, chronic fatigue, psoriasis, and long COVID.
LDN is an off-label medication and can only be offered by compounding pharmacies. Always discuss with your doctor first.
Commercial naltrexone isn’t available in low doses.
Compounding pharmacies like ours precisely customize dosage strengths (e.g., 1.5 mg capsules) to the exact needs of the patient.
This also allows us to incrementally titrate the dosage size as needed.
It briefly blocks opioid receptors, triggering your body to produce more endorphins and modulate immune responses.
This may reduce inflammation and ease symptoms in autoimmune or neurological conditions.
Irritated glial cells can trigger inflammation in the body. LDN inhibits these cells and prevents the pro-inflammatory cytokine cascade associated with the development of chronic pain.
Low doses of naltrexone can have paradoxical analgesic effects. This can help the patient reduce pain symptoms.
LDN can increase the amount of endorphins in patients. The improvement in endorphin function can lead to a reduction in pain in fibromyalgia patients.
Responses to LDN are highly dependent on the individual. Though LDN has relieved pain for many people, it may not work for everyone.
LDN is considered an off-label medication. There is no standard time frame for the healing process.
However, there is an established typical time frame for dosage titration. New patients will generally start with 1.5 mg of naltrexone and increase it by 1.5 mg monthly.
After two months, patients will settle at the 4.5 mg dosage. Naturally, your doctor and pharmacist will help monitor tolerance of the drug and oversee the dosage increase process.
All ClearSpring Pharmacy locations will be closed in observance of Memorial Day, Saturday, July 4th, 2026.
Normal business hours will resume on Monday.
A nationwide shortage of estradiol patches is affecting major pharmacies and may continue for up to 3 years.
Affected brands include:
You don’t need to wait until you run out. Compounding pharmacies are experts at stepping in when drug shortages occur.
We have topical options such as creams or troches, and we work with your doctor to ensure your care stays on track.
