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Trimix Injections for ED

Trimix Injection for ED

What is Trimix?

Trimix injections help solve erectile dysfunction in men. This medication is injected directly into the penis. It is a combination of three medicines:
  • Alprostadil
  • Papaverine
  • And phentolamine

When these three medications are combined, they can provide excellent results for people with ED. This is especially true for men who have not responded to other treatments such as sildenafil (Viagra)tadalafil (Cialis), and vardenafil.

Sometimes, a fourth ingredient, atropine, is added to the medication to make Quadmix.

Trimix and Quadmix Ingredients


A synthetic version of the naturally occurring lipid prostaglandin. This helps to relax the smooth muscles in the penis and increase blood flow.


An alkaloid found in opium, this drug helps dilate blood vessels and improve blood flow.​


Helps blood vessels expand and increase blood flow while also returning sensation.​


Sometimes added as a 4th ingredient to trimix when the patient has a low heart rate.​

How Long Does Trimix Last?

Trimix injections can last 30 minutes to one hour after being injected directly into the penis. The duration of the effect may vary depending on the individual and the dose used.

Some men may experience longer-lasting results, while others may find that the effects wear off more quickly.

If an erection lasts for longer than 4 hours, seek medical attention. Sometimes, Sudafed PE over the counter can help. Otherwise, going to the ER may be necessary.

Age, overall health, and underlying medical conditions can also affect how long the medication lasts. No arousal is needed for an erection when using Trimix.

When to Use Trimix Injections

It’s important to note that Trimix is intended for occasional use, not daily use. Typically, Trimix is used every three days.

Trimix is not for men who have slight ED or only occasionally struggle to develop and maintain an erection. Trimix is for men who have a functional inability to produce an erection. This may be due to:
  • Post-prostatectomy
  • Cancer treatments
  • Traumatic injuries (car accidents, hurt at work)
  • Prostate cancer

When to Use Trimix

Trimix Injection Dosage Size

Your doctor will work with you to determine the best Trimix injection dosage size.

Your initial dose will be taken with your doctor to review the results and make altercations from there. The starting amount is up to your doctor’s discretion but can be 15 – 30 units (0.15ml – 0.3ml).

What Size Is the Trimix Needle?

The needle used for injecting Trimix is a 29 gage. It is around half an inch long.

How to Store Trimix

The best way to store Trimix is to keep it in the freezer. Trimix, when frozen, will last longer than when kept at room temperature or in the refrigerator.

Before using the medication, you can place it on the counter for a few minutes to thaw. Frozen Trimix will last about 45 days.

Sterile Compounding Trimix

Trimix and similar injections can be made by compounding pharmacies, but only by those with a sterile compounding lab.

ClearSpring Pharmacy is one of the only pharmacies in Colorado capable of making sterile compounds. We test our products frequently by sending in random samples and meeting all state requirements.

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