Low dose naltrexone (LDN) is increasingly being recognized for its potential in managing chronic conditions such as autoimmune diseases, chronic pain, and certain mental health disorders. Naltrexone, typically used to treat opioid and alcohol addiction, has demonstrated positive impacts when used in smaller doses.
Some patients experience increased endorphin production, reduced inflammation, and other benefits. But just like any drug, users of LDN may experience side effects. The side effects, however, are generally mild and can be effectively managed.
Doctors typically recommend that patients take LDN before bedtime. Studies show that this could increase endorphin production and improve the effects of the drug. However, a small percentage of patients may experience difficulty sleeping or vivid dreams when first starting LDN.
It usually resolves within a few weeks. For patients who continue to experience difficulty sleeping, they may change the time of day they take the medication or reduce the dosage amount.
During the initial dosing time, patients may experience mild stomach discomfort or gastrointestinal issues.
The body usually has an adjustment period during which patients may experience mild nausea.
A small number of patients report headaches when starting LDN. They are usually mild and diminish as the body adjusts to the medication.
Any severe or persistent headaches should be reported to the healthcare provider for possible dosage adjustments.
Some patients have reported experiencing mental changes and mood swings, including increased irritability.
LDN can sometimes cause temporary fatigue while the body adjusts to the medication. Usually, patients experience reduced fatigue as a benefit of LDN.
Most side effects are temporary and can be managed by adjusting the dosage or time of day the drug is taken. For example, taking LDN in the morning instead of at night might help if sleep disturbances occur.
Generally, side effects will be reduced or disappear after the body adjusts to the initial dosing.
Always consult your healthcare provider before making any changes to your medication regimen.
Many of the side effects that patients experience occur during the onset of treatment. To help alleviate discomfort, prescribers will start with lower doses of LDN and work their way up.
Many patients begin with 0.5 mg and increase by 0.5 mg – 1 mg weekly until they reach the full dose of 4.5 mg. Titration is highly patient-dependent and will only progress if the patient is comfortable.
Overall, LDN is well-tolerated by most patients, with side effects often subsiding after the initial weeks of treatment. If side effects persist or cause significant discomfort, it’s important to consult with your healthcare provider to explore potential adjustments.
For more information, please contact our knowledgeable team via phone or text. We have locations in Littleton and Cherry Creek. Our pharmacists are experienced and will help counsel patients new to taking LDN.
Please contact our pharmacy at either the Littleton or Cherry Creek location.
You can also send us a direct text here:
Littleton: 303-707-1500
Cherry Creek: 303-333-2010
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