Originally used as an anesthetic, ketamine continues to be studied for its impact on people experiencing depression.
Controlled doses of ketamine can act quickly and reduce the debilitating symptoms associated with depression.
Ketamine can provide “rapid, profound, and surprisingly durable antidepressant effects.”
Intranasal ketamine has shown positive results when addressing depressive symptoms. It has emerged as a prominent method of delivering the drug.
Nasal sprays containing ketamine have become more popular as a treatment for depression. In fact, the FDA has approved Spravato as a ketamine-based nasal spray for depression.
This nasal spray can be used in conjunction with antidepressant medicines or for patients who have treatment-resistant depression.
These nasal sprays are to be used in a medical setting and in the presence of medical doctors. However, this stringent process can be inconvenient for patients.
Administering the spray may be difficult if the patient has to visit the doctor every time.
ClearSpring Pharmacy compounds ketamine nasal sprays for patients, allowing them to take the medication in their homes!
The spray is customized to meet the needs of the patient. This includes considerations for prescription strength and base ingredients.
The most common prescription strength is 150 mg/ml and can go as high as 175 mg/ml. Any higher and the compound may not hold correctly.
With preservatives, the spray can last the full 30 days prescribed. Sprays without preservatives will last around 17-21 days before losing stability.
While intranasal ketamine is less effective than intravenous ketamine, it provides a more straightforward administration method that is more user-friendly.
With the proper precautions taking place, patients can conveniently make use of ketamine nasal sprays at an affordable price.
Ketamine takes a different approach to addressing depression compared to traditional medications.
SSRIs (selective serotonin reuptake inhibitors) are commonly prescribed to help treat depressive symptoms. SSRIs increase serotonin levels in the brain by blocking serotonin reabsorption (reuptake) in our neurons.
Serotonin is a neurotransmitter commonly associated with calmness and positive emotions. By inhibiting the removal of serotonin, more is available in our brain to process the “good feelings” repeatedly.
Ketamine does not influence serotonin but instead interacts with glutamate. Glutamate is a neurotransmitter that helps with learning, memory, and the development of neural connections in our brain. This may explain why many people succeed with ketamine after failing with SSRIs.
Additionally, ketamine works faster than SSRIs. Many patients experience an improvement in their depressive symptoms within 24 hours of induction, while SSRIs may take months to take effect.
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DISCLAIMER: A prescription from a licensed practitioner is required for compounded medications.
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