Why is losing weight so hard, even when significantly cutting calories?
Hormones, thyroid functionality, mental health conditions, and more can affect a person’s ability to burn fat.
Low dose naltrexone (LDN) addresses both the physical and mental elements of obesity, making it a holistic option for weight management.
It helps with 4 key components:
Weight loss isn’t just about willpower, sometimes, we actually have to address the chemistry in our bodies.
Responses vary. Some see changes in weeks but in general most will experience the full effects after 2 months of use.
Consistency is key and it is important to track symptoms and work with your prescriber.
Most plans don’t cover off-label compounded medications such as LDN. However, we do provide transparent cash pricing.
Some FSAs/HSAs accept LDN receipts. We are always happy to supply documentation.
You can take the dose as soon as you remember, unless it is within 6 hours of your next dose. Then resume your normal dosing schedule.
Never double dose. If you miss a dose, it is okay to skip it and continue with your dosing schedule.
Most are mild: vivid dreams, sleep disturbances, or temporary headaches.
These often fade within weeks. We adjust doses to minimize reactions.
It briefly blocks opioid receptors, triggering your body to produce more endorphins and modulate immune responses.
This may reduce inflammation and ease symptoms in autoimmune or neurological conditions.
Weight loss largely comes down to burning more calories than you take in.
When we’ve had enough to eat, our bodies signal to our brains to stop.
For some people, it takes more food before they get the “enough” signal, leading to overeating and feeling hungrier overall.
Overeating can significantly impact the body’s metabolism, potentially leading to fewer calories being burned throughout the day.
LDN reduces overeating by dialing down the natural endorphin boost from eating and limiting appetite.
As food becomes less rewarding, patients often learn to better regulate when and how they eat.
Obesity can make it harder for the body to handle inflammation the way it should. Excess weight can exacerbate injuries, prolonging recovery and making weight loss more difficult.
Overproduction of inflammatory cytokines can lead to insulin resistance and weight gain.
Studies have shown that LDN can counter this by reducing inflammation and helping regulate insulin levels. LDN provides these benefits by calming and modulating glial cell activity, promoting weight loss.
Here’s how LDN works, according to clinical studies: When taken at night, it increases endorphin levels. Higher endorphin levels benefit people with autoimmune diseases and reduce inflammation.
At the same time, LDN lowers insulin levels, which then increases adult human growth hormone.
That means patients have a greater chance of holding onto muscle while burning more fat.
Some early evidence points to better sleep quality with LDN. Certain individuals report calming effects, reduced anxiety, and noticeable improvement in sleep apnea symptoms.
Why does poor sleep make weight loss harder?
It spikes cortisol and inflammatory cytokines. Those changes then affect your metabolism and how your body responds to insulin, encouraging fat storage rather than fat burning.
LDN promotes a more natural, consistent pattern of weight loss. It is not a miracle drug. Patients typically lose about 1 to 2 pounds per week.
Other measures are still necessary to help contribute to weight loss, including:
At times, diet and exercise may not be enough for weight loss. LDN helps with a few underlying issues that may be difficult to address through typical means.
Patients can work with their doctors and pharmacists to determine if LDN is a viable option.
We’re always here to help you.
The holidays bring us joy, but they also bring us more prescriptions to fill and ship. Our pharmacy continues to work diligently, but an increase in demand may result in slightly longer processing times.
Please consider doing the following:
Thank you,
ClearSpring Team