Ortho Spore IG

SIBO is a condition that occurs when there is an overabundance of commensal bacteria from the colon present in the small intestine. The health of the small intestines relies on balanced microbiota, and probiotics and immunoglobulins can contribute to that balance by having a positive influence on the intestinal environment, including pH, organism diversity, and immune signaling.

Probiotics have been extensively studied and are characterized as having broad GI and immune benefits. Probiotics are live organisms and must be shelf stable through the expiration date, so they can be precisely delivered to the intestinal tract to have maximum benefit. Bacillus spores remain dormant in harsh environments until they reach more favorable environments like the human gastrointestinal tract. The combination of specific strains, particularly Bacillus coagulans, Bacillus clausii, and Bacillus subtilis, relieve symptoms for common GI complaints and reinforce healthy gut function.

In the search for innovative ways to improve microbiome diversity, we have combined our blend of spore-forming probiotics alongside immunoglobulins uniquely shown to bind to bacteria and toxins, driving immune response. IgG helps to maintain a healthy intestinal immune system by binding a broad range of microbes and toxins within the gut lumen.

Bacillus coagulans
Bacillus coagulans has been shown to increase the commensal GI microbiota. It has been shown to relieve GI discomfort and improve stool consistency. B. coagulans also significantly improved bowel movements in healthy adults with occasional constipation, as well as decreased abdominal discomfort.

Bacillus clausii
B. clausii is commonly used as a probiotic to promote balance in the microbiome and has showed promising results in individuals with SIBO. B. clausii has demonstrated significant effectiveness in adults with acute diarrhea. B. clausii has also shown to significantly reduce duration of occasional diarrhea and decreased stool frequency in children

Bacillus subtilis
Bacillus subtilis has been shown to relieve GI distress in patients.

Serum-derived bovine immunoglobulins
Probiotics are a natural choice for supporting beneficial bacteria in the gut, but supplementation to eliminate unwanted microbes should also be considered. Within the gut barrier, researchers found that the binding capabilities of immunoglobulins have a positive effect on gut barrier function in vitro. Broad-spectrum binding capabilities demonstrate the positive influence of serum-derived bovine immunoglobulins. This binding and elimination decreases microbe and toxin encounters by the immune system and resets immune tolerance.