PureGenomics® B-Complex is designed to address the nutrient requirements of common genetic variations in the methylation pathway with a unique blend of B vitamins in highly researched and activated forms. Methylation is a key regulator of genetic expression and cellular function.
Healthy methylation is vital for cellular health, DNA synthesis, hormone and neurotransmitter production and energy metabolism.1 Optimal levels of B vitamins have been associated with cellular, cardiovascular, neurological and psychological health.2,3,4,5 B vitamins are essential to basal mitochondrial function as metabolic coenzymes, playing a key role in energy production and nutrient metabolism.6
Folate is offered in this formula as Metafolin® 5-methyltetrahydrofolate (5-MTHF), the universally metabolized and biologically active form of folate, providing support for individuals with genetic variations in the MTHFR gene.7
Vitamin B12 is offered as a combination of hydroxycobalamin and adenosylcobalamin. Hydroxycobalamin is a precursor form of vitamin B12 converted in the body to both methylcobalamin and adenosylcobalamin. Adenosylcobalamin is an activated form stored in the mitochondria of cellular tissues. It is a key cofactor in carbohydrate metabolism and healthy synthesis of neuronal myelin.8 Benfotiamine is a lipid-soluble, enhanced-retention thiamin derivative.*
Reference
- Glier MB, Green TJ, Devlin AM. Mol Nutr Food Res 2014 Jan;58(1):172-82.
- Antoniades C, et al. Circulation. 2006 Sep 12;114(11):1193-201.
- den Heijer M, et al. Arterioscler Thromb Vasc Biol. . 1998 Mar;18(3):356-61
- Jacobs AM, et al. Rev Neurol Dis. 2011;8(1-2):39-47.
- Almeida OP, et al. Ann Neurol. 2010 Oct;68(4):503-10.
- Huskisson E, Maggini S, Ruf M. J Int Med Res. 2007 May-Jun;35(3):277-89.
- Prinz-Langenohl R, et al.Br J Pharmacol. . 2009 Dec; 158(8): 2014?2021.
- L?vblad K, et al. Pediatr Radiol. 1997 Feb;27(2):155-8.
